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Another pass at causation with Little & Rubin

25 Sep 2014

This week, we discussed:

Little, R. J., & Rubin, D. B. (2000). Causal effects in clinical and epidemiological studies via potential outcomes: concepts and analytical approaches. Annual Review of Public Health, 21(1), 121–145.

In this article, Little and Rubin lay down some of their requirements for causal inference, including a variety of approaches. Read the full post for some notes and links to python code and angry physicists.

Nailing down our assumptions

Of critical importance is the authors’ claim that a “stable unit-treatment value” assumption (SUTVA) is necessary for causal inference. Put simply, SUTVA breaks down into the following:

  • If one bunny is given a treatment, it doesn’t affect other bunnies.
  • There is no (relevant) variation in treatment.

However, it seems that there are certainly situations in which we could claim causal effects (and can’t assume homogeneity of treatments) – for example, in psychoterapeutic settings, or when compliance with a protocol is violated by some participants.

Michael claims another paper of interest (Interference between units in randomized experiments, by Paul R. Rosenbaum) lays out a version of causal inference that does not require SUTVA.

The authors present three forms of inference.

  1. Fisherian: We demand full randomization, and perform Null-Hypothesis Significance Testing (NHST) on differences between groups.
  2. Neyman’s: We still demand full randomization, and generate a (frequentist) confidence interval around the difference.
  3. Model-based: Compute a bayesian confidence interval. The authors find this to be the most satisfying approach.

A breakdown of these different forms of confidence intervals, including python code is given in this well-circulated blog post by Jake VanderPlas. (But note that it’s not hard to find folks who argue that Jake’s specific examples are ignorant.)